This tutorial is for intermediate users who want to install and useWine on their computer running macOS.You should already know the basics of how to use the command line.If you don't, read this tutorial first.
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What is Wine?
Wine is awesome.No, I'm not talking about the kind you drink,I mean the kind that lets you run Windows apps without theWindows operating system.It's kind of Zen, when you think about it.Oh, and did I mention it's completely free, legal, and open source?
Nowadays, Windows and Mac play nicely together.You can install Windows and Mac side by side and switch between them usingBoot Camp, but that requiresa reboot every time, and you can only use one operating system at a time.You can also use a tool likeParallels Desktop orVMware Fusionto virtualize Windows and run it together with Mac,but virtualization is slow and it takes up a lot of memory.(Your physical computer creates an imaginary 'virtual' computer within itself,and runs Windows on that. That takes a lot of resources!)On top of that, all of these solutions require you to own a legal copyof Windows, which isn't cheap!
Wine is different. When any program runs, it requests resourceslike memory and disk space from the operating system.All that Wine does is make sure that those requests get answered so thatthe program can run correctly. As far as the program knows, everythingis going smoothly because it has everything it needs.It never even realizes that it's not running on Windows!It's simpler than emulating a whole new computer, so it's faster.Since it's just translating requests, you don't need a copy ofthe actual Windows operating system. Plus, Wine is open source,which means people are continually improving it and adding new features.And you can't beat the price!
Will My Program Work With Wine?
A lot of people discover Wine because they have one specific Windows programthat they need to use, and it's the last thing preventing them from switchingto a different operating system. So, the big question is, will it work?The short answer is: probably, but it's worth checking.
The Wine project maintains a database called theAppDB that hasuser reviews of how well specific Windows programs work under Wine.Search for your program and find out! (If it's not listed, that doesn'tnecessarily mean that it won't work — only that you're apparently tryingto use a very obscure program!)
Requirements
To install Wine on your Mac, you will need the following:
- macOS 10.10 (Yosemite) or above (but 10.15 Catalina is not recommended)
- Access to an Admin account, with password
- An internet connection
To check what version of macOS you're running,click on the Apple logo on the far left side of the toolbar,select 'About This Mac', and look at your versionnumber under the big 'macOS' or 'OS X'. If it's 10.10 or higher, you're all set.
Note that Wine does not work well with macOS 10.15 Catalina. Apple removed 32-bit supportin Catalina, which is a critical part of the macOS system that almost all of Wine relies on.You can run 64-bit applications through Wine on Catalina, but very few applications for Windowsare 64-bit. If you need to use Wine, you should not upgrade to Catalina.
You need an Admin account on your Mac because only Admins can install software.You will need to be logged in to this Admin account during the installation.If there is only one account on your computer, it is an Admin account.The account must have a password: if the account has no password,the
sudo
utility will fail. To set or change your password,go to the Accounts section in System Preferences.Part 1: Install Homebrew
Homebrew is a package manager that makes installingopen source programs much easier. In particular, trying to installa large program like Wine without the help of a package manager would betremendously difficult.Fortunately, Homebrew itself is simple to install: just open up theTerminal and run this command:
The Terminal will tell you what it's about to do, and ask youif you want to proceed: press Enter to do so.The Terminal may then ask for a password: this is the passwordto the Admin account on your computer. As a security measure,the Terminal does not display anything as you type, not evenasterisks (*). Type your password anyway, and press Enter. If you get somekind of error, it might be because the Admin account doesn't have apassword set. Setting a password is required.
Installing Homebrew should only take a few seconds or minutes(depending on the speed of your internet connection). When it's done,the Terminal will say that the installation was successful, and ask you torun brew doctor. Do as it suggests:
This will make Homebrew inspect your system and make sure that everythingis set up correctly. If the Terminal informs you of any issues, you'll needto fix them yourself, and then run brew doctor again to verify that youfixed them correctly. When everything is set up correctly, you'll see themessage
Your system is ready to brew
, and you can move on to the next partof the tutorial.Note: If Homebrew tells you that you need to agree to the Xcode license,you can do that by running:
The Terminal window will fill up with the Xcode license:read it, type agree and hit enter to agree to the license.
Part 2: Install Wine Using Homebrew
Now we get to actually install Wine! We'll let Homebrew do all the work,all you have to do is tell it what you want with this command:
Let's break down this command into parts.
brew
refers to Homebrew, whichyou just installed. cask
refers toHomebrew Cask,an extension to Homebrew that is used to install GUI application on yourcomputer. (GUI stands for 'Graphical User Interface'. A GUI application isan app that you can see running, as opposed to invisibly runningin the background.) install
refers to the fact that you're askingHomebrew Cask to install something on your computer, and wine-stable
is the name of the thing that you want it to install. Wine has a 'stable' versionand a 'devel' version: you probably want stable, since it should have fewer bugs.When you run this command, Homebrew will start automatically downloadingand installing software onto your computer. It might start by installingsoftware that has a totally different name: that's fine! Like most complexapplications, Wine doesn't work alone -- it relies on several other pieces of software torun correctly. These are called 'dependencies', and Homebrew is smart enoughto install them for you automatically when necessary.
While it's working, Homebrew will display messages and progress bars on the Terminal to let you know what it's doing. When it's done installing Wine, it will stop displaying messages and wait for you to type in a new command. When that happens, move on to the next step!
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Part 3: Install Windows Programs Using Wine
To install a Windows program, first download the installer file:it should end with .exe. Remember the location you put it, and open upthe Terminal again.
cd
to the location, and use ls
to make sure you cansee the installer file. (Note: if you do not know what cd
and ls
are,you should learn how to use the command linebefore using Wine.)Once you are in the correct directory, run the installer through Wineby running the following command in the Terminal:
Where
$INSTALLER
is the name of the installer file. For example,if the installer file is named setup.exe
, you would run:A window will pop up with a regular graphical Windows installer.Click through it, and you're done!
Part 4: Run Windows Programs Using Wine
Open up the Terminal and run this to get to your Program Files folder:
Run ls to see what programs you have installed. Pick a program,and enter its directory using cd. (If the folder has a space in it,you must type a before the space. For example,
Program Files
.If you're having problems, try using tab autocomplete.)There should be a file that ends in .exe
: this is the program file.Type this into Terminal:Where
$PROGRAM
is the name of the .exe
file. For example, if the programfile is named STARCRAFT.EXE
, you would run:The program will pop up in a new window, ready to use!Enjoy using Windows on your Mac, freely and legally!
Making a Dock Icon
Many people want to be able to run Windows programs the same waythey run other programs on the Mac: by clicking an icon in the Dock.Wine isn't specifically designed to support this, but with a little trickery,we can make it do what we want.
Autocad civil 3d 2015 free with crack. Note: Wine prints out error messages in the Terminal when something goes wrong.By launching Windows programs via a Dock icon, you are sidestepping theTerminal, which means that if something does go wrong and Wine has to quit,it will not be able to tell you what the problem was. The first stepto solving a problem is knowing what it is, so without running Winefrom the Terminal, you won't be able to fix it, and neither will anyone else.Running from the Dock is fine as long as your program seems to be workingcorrectly, but if it crashes, the first thing you should try is running itfrom the Terminal instead: it won't prevent the program from crashing,but it will give you some clues on how to fix the problem.
In order to launch a Windows program via the Dock, we're going towrite an AppleScriptthat launches the program for us, and then putthat AppleScript in the Dock. Essentially, we're writing a program ourselves!Don't worry, it's easy enough. There is a program on your computerthat is designed for helping you write AppleScripts:it's called 'Script Editor', and you can find it in the
/Applications/Utilities
directory of your computer,same as the Terminal itself.Open up the Script Editor. You should see a window with a large areayou can type in near the top: this is where you write your AppleScript.In that area, type the following text:
You'll need to replace
$PATH_TO_PROGRAM
with the path from theProgram Files directory to your program executable. You can see thatyou're simply telling the AppleScript to run a line of code in the Terminal:the same line of code that you could run to start your Windows program.Bioedit Per Mac
Next, press the Compile button at the top of the window.The text should become colored to indicate that Script Editorunderstands what you wrote. You can also try pressing the Run buttonto run your script: it should open the Windows program successfully.
Lastly, save your script. You can give it whatever name you'd like,but be sure to select File Format: Application in the save options,and leave Startup Screen unchecked.
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Open up the Finder, go to where you saved your script, and drag thatfile to your Dock. It should stay there, just like a real application — because it is a real application! However, all it does is runthat launcher command for you, so you can move the application around,rename it, or even delete it, and it won't affect the Windows programthat you're running.
Keeping Wine Up to Date
Wine is an open source program. That means that programmersaround the world are continually improving it, adding new featuresand squashing bugs. If you don't update Wine, though, it will neverget those improvements, so it's generally a good idea to check for updatesevery so often. Intel 82578dc driver windows 10. We can use Homebrew to keep Wine up to date: it's easy!Just run this command:
With this command, Homebrew will first update itself, if any updatesare available. It will then find all the outdated software it knows about(including Wine) and upgrade them all to the latest version.Checking for updates isn't strictly necessary, as Wine runs quite wellcurrently. However, it's a good idea to run this command every few monthsor so.
Uninstalling Wine and Homebrew
If you try Wine and you don't like it, uninstalling it is easy.Just run this command:
And Homebrew will helpfully remove Wine from your computer.However, in order to install Wine, Homebrew also had to install many othersmall programs that Wine relies upon to work correctly.(That's why the install process takes so long!)If you want to remove these as well,run this script:
That script will remove everthing that you installed in this tutorial,including Homebrew, Wine, and all the other programs Homebrew installedto get Wine to work correctly.
Please enable JavaScript to view the comments powered by Disqus.Tom Hall. North Carolina State University, Department of Microbiology. This is likely to be the final release of BioEdit. There may be some bugs. BioEdit is a mouse-driven, easy-to-use sequence alignment editor and sequence analysis program designed and written by a graduate student. BioEdit can also edit chromatograms, but I find Chromas to be nicer. MEGA also has an alignment editor, but I’ve not really used it very much. Double click on the .
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Windows outlook s. You can download my bioedit. When I am done I save the chromatogram and export the data to a line file which is saved with a.
To change settings first create a new alignment File, New Alignment or open an existing file. Each line in the trace is colour-coded to match the colour that one of the 4 bases is displayed in. Then I undo the cut, select all the sequences Edit, Select All Sequences, control-shift-acopy them control-a–note that copy and pasting sequences is different to any other copy and paste action. Identify the region of vector sequences. Chromas has the advantage the you can save all of your chromatograms which can subsequently be used in any other programs unlike Sequencher which saves everything tutroial a project file which cannot be opened by anything else.
I use BioEdit to align sequences as it is free and has some handy features. Hit save control-shift-s and repeat for each group of sequences.
BioEdit Tutorials – Practical Bioinformatics
Select to the end including the current residue. These should show an almost exact match to the forward or reverse sequence.
I check any unique differences by opening the chromatogram. For each gene within a dataset I bioevit have this file with the forward, reverse and consensus.
All of that probably sounds very confusing, once you have carefully worked through it a couple of times it becomes very easy.
Click on the File menu, New alignment. There is no auto save function. Now I select all gutorial forward sequences and cut them and scroll right to check for any bases changes that need to be checked. Move cursor between the residue and the previous residue.
Select gioedit files with the mouse by dragging it over the file names at the left. Now when you double click on a chromatogram it will open in Chromas. To fix this, right click on a chromatogram, select properties, it should say opens with BioEdit, hit change, browse to the Chromas executable, select it, choose always open with this program, hit ok.
It can be helpful to make sure any missing bases bioediit labeled with an n, only use a – for indels so that you can easily distinguish which is which. Save the file as text only and make sure it has the correct file extension. I usually make all of my edits as lower case bases as it makes it easier to identify where I have made edits. Double tugorial on the chromatogram file usually has the extension ab1.
At that point I finish my consensus sequence. If this does not occur, repeat the process with the reverse complement sequence file in a New alignment.
Sequence editing using BioEdit
See sequence analysis references for full map. It helps to also have additional individuals from the same population all next to one another too. Now scroll right again and look for any bases that need checking. Overwrite the sequence title onto the next title shifting up, when the title is being edited. If the vector sequence given is the opposite strand to the forward sequence, then there should be a region of almost exact homology with the end of the reverse complement.
Drag residues with the mouse left button on. Enter that information in the header of the MEGA file. One quirk of BioEdit is that if you double click a data file it will open in a new copy of BioEdit, not in an existing one. I select a point in the reverse, then select sequence to the end Edit, Select to End, control-e. Select the value you wish to change, hit the value on the keyboard and that will reset it.
Guide to editing sequences with Chromas and BioEdit
Figure out how many base pairs are present in BioEdit, go to the last base and select it and look at the number. Editing and most of the analysis will be done using BioEdit, a freeware sequence analysis program developed by Tom Hall at North Carolina State University.
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Close BioEdit, reopen your files and the settings should all be saved.